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Which of the following is not true of hematopoietic stem cells?

They first appear during development in the yolk sac and the posterior aorta.

They are rare cells that express particular surface markers and have a unique morphologic appearance.

They are nurtured in a niche in the bone marrow that is close to blood vessels and stromal cells that express the chemokine CXCL12.

They can be obtained for therapeutic purposes from the bone marrow, umbilical cord blood, or peripheral blood.

They are the only hematopoietic cells that possess the properties of self-renewal and multipotency.

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The correct answer is B.

Explanation:

Hematopoietic stem cells are indeed rare, and they express a characteristic set of surface markers. However, the morphology of these cells is not unique. They resemble mature circulating blood lymphocytes.

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